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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK7
All Species:
29.09
Human Site:
Y246
Identified Species:
42.67
UniProt:
P50613
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50613
NP_001790.1
346
39038
Y246
D
M
C
S
L
P
D
Y
V
T
F
K
S
F
P
Chimpanzee
Pan troglodytes
XP_518193
305
34323
H217
S
F
P
G
I
P
L
H
H
I
F
S
A
A
G
Rhesus Macaque
Macaca mulatta
XP_001092242
346
39008
Y246
D
M
C
S
L
P
D
Y
V
T
F
K
S
F
P
Dog
Lupus familis
XP_850424
354
39795
F254
D
M
C
S
L
P
D
F
V
T
F
K
S
F
P
Cat
Felis silvestris
Mouse
Mus musculus
Q03147
346
38950
Y246
D
M
C
S
L
P
D
Y
V
T
F
K
S
F
P
Rat
Rattus norvegicus
P51952
329
37122
Y238
D
M
C
S
L
P
D
Y
V
T
F
K
S
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506541
324
36280
Y224
G
M
T
S
L
P
D
Y
V
T
F
K
S
F
P
Chicken
Gallus gallus
P13863
303
34670
I216
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
Frog
Xenopus laevis
P20911
352
39672
Y252
G
M
S
S
L
P
D
Y
V
A
F
K
S
F
P
Zebra Danio
Brachydanio rerio
A8WIP6
344
39006
Y237
E
I
T
E
L
P
D
Y
N
K
I
T
F
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511044
353
39655
Y246
H
L
S
K
L
H
D
Y
L
Q
F
R
N
F
P
Honey Bee
Apis mellifera
XP_395800
321
36188
F225
G
M
T
E
L
P
D
F
I
Q
F
K
P
F
P
Nematode Worm
Caenorhab. elegans
P34556
332
38277
L244
V
L
G
T
P
T
E
L
E
W
N
G
V
E
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
E209
P
L
F
P
G
D
S
E
I
D
E
L
F
K
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LMT0
391
44511
Y243
D
L
T
K
L
P
D
Y
V
E
Y
Q
F
V
P
Baker's Yeast
Sacchar. cerevisiae
P06242
306
35228
A220
Q
M
E
V
T
F
R
A
L
G
T
P
T
D
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.1
99.7
92.6
N.A.
95
91
N.A.
87.5
39.8
85.2
42.2
N.A.
65.7
63.8
39.3
N.A.
Protein Similarity:
100
88.1
99.7
95.4
N.A.
96.8
92.4
N.A.
88.7
56.3
90.3
59.5
N.A.
78.4
75.1
57.5
N.A.
P-Site Identity:
100
13.3
100
93.3
N.A.
100
100
N.A.
86.6
13.3
80
26.6
N.A.
40
53.3
0
N.A.
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
86.6
26.6
80
40
N.A.
66.6
66.6
20
N.A.
Percent
Protein Identity:
N.A.
39.3
N.A.
49.1
41
N.A.
Protein Similarity:
N.A.
57.8
N.A.
65.2
60.6
N.A.
P-Site Identity:
N.A.
0
N.A.
46.6
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
66.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
7
7
0
7
7
0
% A
% Cys:
0
0
32
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
38
0
7
0
0
7
69
0
0
7
0
0
0
7
0
% D
% Glu:
13
0
7
13
0
0
7
7
7
7
7
0
0
7
7
% E
% Phe:
0
7
7
0
0
13
0
13
7
0
63
0
19
57
0
% F
% Gly:
19
0
7
7
7
0
0
0
0
7
0
7
7
0
7
% G
% His:
7
0
0
0
0
7
0
7
7
0
0
0
0
0
0
% H
% Ile:
0
13
0
0
7
0
0
7
13
7
7
0
0
0
7
% I
% Lys:
0
0
0
13
0
0
0
0
0
7
0
50
0
13
0
% K
% Leu:
0
25
0
0
75
0
7
7
13
0
0
13
0
0
0
% L
% Met:
0
57
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
0
7
0
7
0
0
% N
% Pro:
7
0
7
7
7
69
0
0
0
0
0
7
7
0
69
% P
% Gln:
7
0
0
7
0
0
0
0
0
13
0
7
0
0
0
% Q
% Arg:
0
0
0
0
0
0
13
0
0
7
0
7
0
0
7
% R
% Ser:
7
0
13
44
0
0
7
0
0
0
0
7
44
0
7
% S
% Thr:
0
0
25
7
7
7
0
0
0
38
7
7
7
7
0
% T
% Val:
7
0
0
7
0
0
0
0
50
0
0
0
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
57
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _